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Markant Medical Communications

SAMPLES

News

Pacritinib Improves Symptoms for Myelofibrosis Patients

Hyperthermia Augments Chemotherapy in Sarcoma Patients

CME Needs Assessments

CAR T-Cell Therapy in the Treatment of B-Cell Malignancies

Manuscripts

Targeting BCL2 in Hematologic Malignancies. Annotated Manuscript, 2018.

Rare Diseases in Hematology. 2018.

Targeting Sonic Hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-Like Kinases. Cancer Research, 2013.

Personalized mice: modelling the molecular heterogeneity of medulloblastoma. Neuropathology and Applied Neurobiology, 2012.

Other Publications

Brun SN, Markant SL, Esparza LA, Garcia G, Terry D, Huang JM, Pavlyukov MS, Li XN, Grant GA, Crawford JR, Levy ML, Conway EM, Smith LH, Nakano I, Berezov A, Greene MI, Wang Q, Wechsler-Reya RJ. Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. Oncogene. 2014 Sept 22.

Kool M, Jones DT, Jäger N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 2014 Mar 17;25(3):393-405.

Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ. Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene. 2012 Oct 8.

Pei Y, Brun SN, Markant SL, Lento W, Gibson P, Taketo MM, Giovannini M, Gilbertson RJ, Wechsler-Reya RJ. WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development. 2012 May; 139(10): 1724-33.

Lau J, Schmidt C, Markant SL, Taylor MD, Wechsler-Reya RJ, Weiss WA. Matching mice to malignancy: molecular subgroups and models of medulloblastoma. Childs Nerv Syst. 2012 Apr; 28(4): 521-32.

Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell. 2009 Feb 3; 15(2): 135-47.

Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell. 2008 Aug 12; 14(2): 135-45.

Qiu XB, Markant SL, Yuan J, Goldberg AL. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 2004 Feb 25; 23(4): 800-10.

Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol. 2002 Dec; 3(12): 1169-76.

For more information, please contact:

Shirley Markant, PhD

smarkant@markantmedical.com

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